The museum spreads over 4,800 square metres (52,000 sq ft). Its six floors are divided into four theme areas, including a historical review of all Alfa Romeo road cars produced since 1910, prototypes and "dream cars", aircraft and aeronautical projects, and scale models and awards.
The museum has over 250 cars and 150 engines, of which approximately half are on view. These include at least one example of each model produced, plus prototypes and racing cars. The museum cars are also displayed on different car related happenings, like Pebble Beach Concours d'Elegance, Goodwood Festival of Speed and Mille Miglia.
At the beginning of 2009 the museum closed for renovations and opened in the end of 2009 to celebrate Alfa Romeo’s 100th birthday in 2010.
As of February 2011, the museum has been "closed for renovation". Right now, it is unclear if the museum will ever reopen. FIAT (owners of Alfa Romeo) have only confirmed that the museum is closed until further notice.